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Este es un tutorial en linea que estamos desarrollando un grupo de usuarios de la página del “Feis” formacionprofesional.info de. Zaragoza se convertirá esta semana en la capital de la inmunología y de la inmunoterapia del cáncer. Más de 3. 50 expertos de todo el país analizarán la relación entre el sistema inmunológico y las enfermedades autoinmunes y oncológicas dentro del congreso nacional de la Sociedad Española de Inmunología que se celebra en el Paraninfo de la Universidad de Zaragoza entre el 2. El objetivo de este encuentro nacional es el de compartir resultados, actualizar conocimientos y establecer colaboraciones en el ámbito de la Inmunología, disciplina que estudia la respuesta del sistema inmunitario contra agresiones externas, normalmente agentes infecciosos, y contribuye a mejorar esas defensas, mediante vacunas o de otros tratamientos de inmunoterapia. De hecho, entre los hitos de la Inmunología en los últimos tiempos destacan los tratamientos de inmunoterapia del cáncer, que están obteniendo resultados excelentes en algunos tipos de cáncer cuyo tratamiento no era efectivo, tal como apunta Alberto Anel, profesor del Departamento de Bioquímica y miembro del grupo de Excelencia en Investigación “Apoptosis, Inmunidad y Cáncer” dela Universidad de Zaragoza, y organizador del comité científico del congreso nacional. Uno de los principales temas que se abordarán en el congreso, entre otros, es el resultado de la utilización de anticuerpos bloqueantes de la molécula PD- 1, aprobados en los últimos años, para el tratamiento del melanoma, del cáncer de pulmón, cáncer renal y cáncer de cabeza y cuello así como de gran cantidad de ensayos clínicos se están llevando a cabo en otros tipos de cáncer y con otras nuevas aproximaciones de inmunoterapia. Precisamente, este trabajo entre oncólogos e inmunólogos está permitiendo nuevas vías de estudio sobre posibles biomarcadores que puedan predecir la respuesta a esos tratamientos. En relación con esta última revolución en el tratamiento del cáncer, se ha organizado también un minisimposio internacional sobre Inmunoterapia del Cáncer para mañana miércoles por la tarde (2. Mayo) en el Caixa. Forum, un día antes de que comience el congreso de la SEI, intentando conjugar los intereses comunes que empiezan a tener ya oncólogos e inmunólogos. Pero no todo es inmunoterapia del cáncer en la Inmunología, insiste el organizador del congreso Alberto Anel. De hecho, el congreso de la SEI se abrirá con una sesión sobre vacunas que todavía se nos resisten, donde Carlos Martín, investigador principal del Grupo de Genética de Micobacterias, y responsable de la línea de Investigación “Construcción de Nuevas Vacunas contra la Tuberculosis” de la Universidad de Zaragoza, hablará sobre los últimos avances de la vacuna aragonesa contra la tuberculosis y Mariano Esteban, del Centro Nacional de Biotecnología, hablará sobre los avances en la vacuna del VIH. También se analizarán otros aspectos más clínicos relacionados con la Inmunología, como el tratamiento y detección de enfermedades autoinmunes, cada vez de mayor prevalencia entre la población, o de las inmundeficiencias primarias hereditarias. Habrá también ocasión de escuchar a expertos internacionales invitados a las conferencias plenarias (verhttp: //congreso- inmunologia. Marina Dobrovolskaia, del National Cancer Institute de Estados Unidos, especializada en Nanotecnología; Federica Sallusto, del Institute for Research in Biomedicine, de Bellinzona en Suiza, especialista en los linfocitos T en la salud y la enfermedad, y Guido Kroemer, prestigioso científico austriaco ubicado en París y director del grupo “Apoptosis, Cancer and Immunity” del INSERM francés, creador del concepto de muerte celular inmunogénica, clave en los avances de la inmunoterapia del céncer. En Aragón existen diferentes grupos de investigación relacionados con la Inmunología, entre ellos algunos investigadores que trabajan, todavía a nivel experimental, en el campo de la inmunoterapia de las enfermedades autoinmunes y del cáncer. Estos son los grupos de Alberto Anel, organizador del congreso, y Luis Martínez, del Servicio de Inmunología del hospital Clínico Lozano Blesa, y el grupo de Julián Pardo, investigador de la Fundación Aragón I+D (ARAID), que se ubica en el Centro de Investigación Biomédica de Aragón (CIBA, centro UZ- IACS). Entre los trabajos que desarrollan estos aragoneses destacan los siguientes trabajos: Activación de células asesinas. El equipo de Julián Pardo estudia el papel de las granzimas, proteínas que defienden de las infecciones virales y también nuevas funciones de estas enzimas en relación con la inflamación, cuyos resultados se podrían aplicar a la terapia de enfermedades autoinmunes y del cáncer. Además, este grupo ha desarrollado protocolos de activación de células “asesinas naturales” humanas (NK, del inglés “natural killer”), que aumentan la capacidad anti- tumoral de estas células sobre tumores sólidos, algunos de ellos resistentes a los tratamientos de quimioterapia, y que podrían tener aplicación en el tratamiento de estos u otros tumores. Liposomas muy eficaces. El grupo de investigación de Luis Martínez patentó la utilización de unos liposomas recubiertos de una proteína que las células del sistema inmune utilizan para matar a células infectadas por virus o a células tumorales, llamada Apo. TRAIL. Se demostró inicialmente que estos liposomas eran un tratamiento de gran eficacia en un modelo experimental de artritis reumatoide en conejos. Posteriormente, se ha demostrado que estos liposomas son mucho más eficaces que la proteína en forma soluble en la eliminación de células tumorales, demostrándose además su actividad sobre células tumorales resistentes a la quimioterapia. En estos momentos se están llevando a cabo experimentos con estos liposomas en modelos animales de desarrollo tumoral. La potencialidad de la proteína granulisina. Finalmente, el grupo de Alberto Anel ha patentado la utilización de otra proteína presente en los linfocitos y activa sobre microbios y células tumorales, llamada granulisina, en el tratamiento del cáncer. Se ha demostrado la eficacia de esta proteína como tratamiento en modelos animales de desarrollo tumoral, en concreto, cáncer de mama y mieloma múltiple. Windows Movie Maker - Download Gratis. Windows Movie Maker per Windows Vista è l'editor video di casa Microsoft incluso di default in tutti i pc con Windows Vista preinstallato. Questo editor video possiede discrete funzionalità, che vanno dalle basilari alle medie esigenze. Non è assolutamente adatto ai professionisti del settore di video making ma può rivelarsi un ottimo alleato per l'utilizzo domestico, risultando perfetto per tutti gli utenti tradizionali che possono aver bisogno di un editor video soltanto occasionalmente, per realizzare brevi collezioni di foto, piccoli video ricordo ed altri semplici file, magari unendo tra loro due o più filmati girati ad esempio con lo smartphone. Questo software permette di editare più file contemporaneamente perché è basato sul classico sistema a timeline. La timeline è una barra temporale strutturata su più livelli all'interno della quale possono essere trascinati sia spezzoni di video che immagini e file audio, da sfruttare magari come colonna sonora o commento aggiuntivo alle immagini (è il caso dei commenti audio registrati direttamente attraverso un microfono collegato al proprio pc, come ad esempio quello comunemente incluso nelle webcam, ormai inserite praticamente di regola all'interno di qualsiasi pc portatile). Con Windows Movie Maker per Windows Vista potrete inoltre editare i file video già pronti per la visione, come ad esempio i filmati girati con smartphone e videocamere. Potrete abbassare ed aumentare il volume dell'audio, coprirlo inserendo effetti sonori o brevi file musicali, tagliare una o più scene considerate inutili e fare tutti gli eventuali copia/incolla del caso, perfetti sia per abbreviare il filmato dandogli un maggiore senso logico che per, eventualmente, collegare tra loro più file video, unendoli con l'aiuto o di stacchi netti o meglio ancora adoperando dei semplici effetti di transazione, perfetti per rendere il tutto più armonioso. Il programma vi consentirà, una volta creato il vostro video ideale a partire da foto, file audio o file video già preesistenti, di esportare il tutto in uno dei tre formati supportati, ovvero AVI, WMV o WMA. Purtroppo i formati in export supportati dal software sono veramente pochi; una scelta così scarna lascia di certo a desiderare, ma non disperate. Se WMV e WMA sono compatibili quasi soltanto con la riproduzione tramite pc, il formato AVI è invece uno tra i più comuni in assoluto e non avrete di certo alcun problema nel riprodurre i vostri amati filmati anche tramite device esterni e lettori dvd. Hai iniziato ad usare Snapchat da poco e ti sembra che gli snap e le storie dei tuoi amici siano molto più belli e smart dei tuoi? Non ti turbare, ecco una lista di.Viene descritto come utilizzare lo strumento controllo File di sistema per problemi relativi ai file di sistema mancanti o danneggiati in Windows 8.1, Windows 8. Avete aggiornato il PC e vi ritrovate di fronte una schermata di copia pirata di Windows? Questo è dovuto al fatto che in seguito all’aggiornamento avete scaricato. Altra funzione importantissima del programma è quella che consente di ruotare, rallentare o velocizzare tutto il video o le sue singole parti. E' una funzionalità innovativa e perfetta per risolvere alcuni tra i più frequenti pasticci combinati in fase di registrazione, come ad esempio l'erroneo orientamento della fotocamera o del cellulare che, registrando tutto sotto sopra, renderà pressoché inutilizzabile il file finito, se non ricorrendo ad un veloce raddrizzamento. Le impostazioni avanzate del programma consentiranno inoltre di modificare il bitrate dei video, la risoluzione del file finale e la dimensione dei filmati. Windows Movie Maker per Windows Vista supporta alcuni tra i più rinomati formati audio e video, come quelli MP3, AVI e MPEG. Non supporta però i comunissimi formati MP4 e MOV: per utilizzare file di questo tipo all'interno del software sarà prima necessario convertirli in uno dei formati supportati, possibilmente cercando di mantenerne inalterate le dimensioni e la qualità; per fare questo sarà assolutamente necessario un programma proveniente da terze parti preposto ad effettuare l'operazione. Windows non dispone attualmente di nessun tipo di programma di default per la conversione dei dati. Tra le caratteristiche più salienti troviamo sicuramente la possibilità di migliorare i propri filmati correlandoli di effetti speciali di tutto rispetto. Con pochi semplici click riuscirete a far assumere ai vostri video un'aria retrò (magari applicandovi gli effetti bianco e nero o seppia); renderli più nitidi e piacevoli alla vista andando ad interagire con i comandi per l'editing delle immagini (contrasto, luminosità, saturazione e molto altro ancora); o ancora effettuare zoom ed aggiungere grane ad effetto pellicola a tutto il filmato o ai singoli frame. Windows Movie Maker per Windows Vista è inoltre munito di splendidi effetti per la transazione delle immagini. Sono disponibili delicati effetti di dissolvenza, in grado di regalare un risultato del tutto naturale e dall'aspetto professionale; effetti di dissolvenza a ventaglio, a filigrana, a comparsa e scomparsa. Insomma, tutto il necessario per fare di un semplice video amatoriale messo su in totale inesperienza un vero e proprio gioiellino realizzato a regola d'arte. Conservare i propri ricordi e conferirgli un valore maggiore non è mai stato così semplice. L'interfaccia grafica è curata e semplicissima da utilizzare: il programma è pensato per gli inesperti e proprio per questo motivo prendere dimestichezza con le funzionalità di base non sarà un problema davvero per nessuno. Nell'effettuare il download non fatevi ingannare dalla ridotta dimensione del file, e munitevi comunque di una connesione stabile e potente. I 1. 3MB del file principale infatti vi consentiranno di scaricare non il file di installazione del programma ma un semplice download helper, ideato per poter scaricare con un solo click Windows Movie Maker per Windows Vista e tanti altri programmi gratuiti messi a disposizione da Microsoft. Pro. E' semplicissimo da utilizzare, perfetto per gli utenti meno esperti. Consente di realizzare in pochi minuti filmati carini e piacevoli da riguardare. E' tutto sommato dotato di più o meno tutte le funzionalità di base per l'editing video amatoriale. Contro. Potrebbe richiedre prestazioni hardware elevate o comunque superiori alla media. Non consente elevati livelli di personalizzazione: è ricco di effetti e funzionalità ma tutte piuttosto basilari. Permette l'export in 3 soli formati, anche se piuttosto comuni. Windows Movie Maker è una specifica versione dell'omonimo programma già presente di default in Windows XP, pensata però per chi utilizza Windows Vista. Conosciuto e utilizzato da molti utenti già da diverso tempo, Windows Movie Maker è uno dei migliori programmi con cui montare i propri file audio e video e realizzare lavori divertenti e di buona professionalità. Questa versione del software è stata pensata per chi utilizza come sistema operativo Windows Vista. In alcuni casi funziona comunque anche su Windows 7; in alternativa, per quest'ultimo sistema operativo, si può scaricare il programma Wax, praticamente identico ma con menu solo in inglese. Gratuito e con interfaccia anche in italiano, Windows Movie Maker offre tantissime opzioni di montaggio: si possono segnalare ad esempio la possibilità di rimuovere l'audio originale del filmato caricato, aggiungere un nuovo file audio registrato sul momento, unire diversi spezzoni tagliando quelli non necessari, impostare il bitrate del nuovo file, e creare accompagnamenti musicali, animazioni, transazioni ed effetti speciali su misura in base alle proprie esigenze e alla propria creatività. Windows Movie Maker per Windows Vista legge quasi tutti i formati audio e un buon numero di formati video, ma ha qualche limite: non supporta infatti estensioni spesso utilizzate come MP4 o MOV, quest'ultima usata di frequente per i filmati girati con macchine fotografiche digitali. In questi casi è necessario modificare preventivamente il file originario, operazione che si può effettuare senza troppe difficoltà con programmi come l'efficace Format Factory. Alcune volte può capitare che dopo molte ore di lavoro il Movie Maker si blocchi all'improvviso, per cui è sempre bene salvare spesso le modifiche che si stanno compiendo, così da evitare il rischio di perdere i dati già acquisiti. I nuovi filmati realizzati al termine del lavoro di editing possono essere salvati in tre specifici formati: il classico AVI, WMV e WMA. Pro. Programma gratuito con interfaccia in italiano. Numerose opzioni per creare filmati con tante possibilità di personalizzazione. Utilizzo semplice e intuitivo. Contro. Questa specifica versione funziona solo su Windows Vista e in alcuni casi su Windows 7. Alcuni formati video come il MOV non sono supportati. Microsoft Office 2007 Blue Edition Tested And Proven Scripture· Microsoft. The fiercely competitive software giant is positioning its wares for cloud computing with software and services. The company's two cash cows - operating. InformationWeek.com: News, analysis and research for business technology professionals, plus peer-to-peer knowledge sharing. Engage with our community. Tabtight professional, free when you need it, VPN service. Microsoft Office 2007 Blue Edition Tested And Proven Or ProvenWorld's Best Teens Compete in Microsoft Office World Championship. This July, we asked for software tips from the 2. Microsoft Office National Champions, a set of charming teens who are officially the best at using Power. Point, Word, and Excel. The Verge recently followed these teens to the World Championship in California, where they tested their Office skills in a contest that out- nerds the spelling bee.“It was as if the Olympics opening ceremony was replaced by a networking event,” says the Verge. The event demonstrates Microsoft’s global dominance, as forty- nine countries competed, though the Verge found that many international competitors chose to compete in English over their native language, as the company’s localized software is poorly translated. Each year, hundreds of thousands of American teenagers compete to be the best at Word, Excel, and…Read more Retired teacher Mary Roettgen, who coached the frequent national champions from Green Hope, NC, is proud of her high- achieving team, but she gives the Verge a hack for getting her A students to help teach her D students: [Roettgen] sets goals for her students — like getting 2. I’d chip in 2. 0 bucks and we’d have a celebration in class.” That had the effect of motivating the A students to help their struggling classmates. And what’s even neater, is that kid who was the 2. Roettgen, who’s just trying to make us cry now, goes on: “You take that D or F student, and get them to pass? It can change their life. Somebody’s just got to tell them they’re worth something.”The Docx Games: Three Days at the Microsoft Office World Championship | The Verge. Bing's US Market Share Is Wildly Underestimated. Microsoft claims Bing, its search engine for people who have just unboxed a new computer and are trying to find out where to download Chrome, is bigger than you think. Stats released by the company this week claim Bing enjoys an astonishing 3. US, which is far higher than the frankly more believable 9 percent it reports worldwide. According to Microsoft, the 3. This is surprising, because as Ars Technica’s Peter Bright noted, the most common reaction he gets when he says he uses the site at all is slack- jawed stares and stupid questions. I, for one, can’t remember a single time I’ve used Bing in recent memory, other than the aforementioned use of installing a web browser that doesn’t use Bing. If Microsoft’s metrics are to be believed, it’s quite a coup: Half a decade ago, some rankings had it come in at under 3 percent of global searches. The numbers seem to go up and down depending on the source, but the most generous prior estimate (from Comscore last year) put Microsoft at just north of 2. Bing technology powers Yahoo’s search engine. None of that counts mobile queries, where Google has a functional global monopoly with virtually no meaningful competition whatsoever. So few web- savvy people seem to use Bing that those who do are a sort of curiosity, though that might just be compartmentalization: If you’re a heavy Google user, using Chrome tied to a Gmail account, it might not ever occur to you that Bing even exists. But since the vast majority of new computer sales are for Windows devices, which come preloaded with Bing- defaulting browsers Internet Explorer or Edge, one would imagine there’s enough workplace users, old people, folks who don’t give a damn and others of their ilk to make up a big share of the market. They’re real and they’re out there, just Binging it up, occasionally not noticing sand penises.[Ars Technica]. |
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